Unicode uses 2 bytes to represent the characters. Unicode system can represent more than 65000 characters. It has a unique code for every character. It covers almost popular languages like English, Hindi and more.
ISCII(Indian Standard Code for Information Interchange) uses 8 bit to represent Indian Language character. It is an extension of the 7 bit ASCII code. It includes 10 Indian scripts which have originated from the Brahmi Script.