| S. No | Innate Immunity | Acquired Immunity |
| (i) | It is a non-specific type of defence present from the birth in an individual and is inherited from the parents. | It is pathogen specific which is not present from the birth and develops through vaccination. |
| (ii) | It does not cause side-effects. | It cause certain reaction against vaccination |
Innate immunity can be accomplished by the following barriers
(i) Physiological barriers: Tears in eyes, acid in the stomach, and saliva in mouth, etc. prevent microbial growth.
(ii) Cytokine barriers: Interferons produced by virus-infected cells protect non-infected cells from further viral infection.