The empirical mass formula is
M(A, Z) = Z(mp+me)+(A−Z)mn−αA+βA2/3 +γ (A−2Z)2 /A+εZ2A−1/3
where α, β, γ and ε are constants. Holding A as constant, differentiate M(A, Z) with respect to Z and set ∂M/∂ Z = 0.
∂ M/∂Z = mp + me − mn − 4γ(A − 2Z)/A + 2εZA−1/3 = 0
The terms mp+me−mn ≅ mH, the mass of hydrogen atom which is neglected. Rearranging the remaining terms, we obtain
Zmin = A /(2 + (ε/2γ )A2/3)
which is identical with the given expression