we might allow mixing when you can use the resulting output mixture, say it is the same substance. You may also allow it if you definitely want the outgoing mixture, like water out of a faucet where you mix hot and cold water. Even if it is different substances it may be desirable, say you add water to dry air to make it more moist, typical for a winter time air-conditioning set-up.
In other cases it is different substances that flow at different pressures with one flow heating or cooling the other flow. This could be hot combustion gases heating a flow of water or a primary fluid flow around a nuclear reactor heating a transfer fluid flow. Here the fluid being heated should stay pure so it does not absorb gases or radioactive particles and becomes contaminated. Even when the two flows have the same substance there may be a reason to keep them at separate pressures.
