The global transfer of ** in the pre-modern world helped in the colonisation of the Americas because the Native ** Indians were not immune to the ** that the settlers and colonisers brought with them. The Europeans were more or less immune to small pox, but the Native Americans, having been cut from the rest of the world for millions of years, had no defence against it. These germs **** and wiped out whole communities, paving the way for foreign domination. Weapons and soldiers could be destroyed or captured, but **** could not be fought against.
